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Lipid Removal from Biological Solutions

At Carl Stuart Ltd we are the specialist channel for LRA® (Lipid Removal Media),used in chemical, API, and biologicals manufacture for the removal of lipids to protect chromatography columns and protect final sterile filters. LRA® has also been shown to be a very effective method of endotoxin removal from biological and pharmaceutical solutions.

LRA® Sorbent Media

Intended Use: LRA media is intended to be used as a lipid sorbent in the production of biopharmaceuticals. LRA media is also used in sample preparation and solid phase extraction. LRA media provides outstanding performance in terms of lipid capacity, filterability, product recovery, and scalability.

Composition: LRA media is a synthetic calcium silicate hydrate. It is composed of 32% calcium oxide, 48% silicon dioxide, and residual levels of sodium, magnesium, and iron.

Lipid Specificity: The specificity of LRA media for lipids and lipoproteins is high, allowing for removal of contaminating lipids from biological streams without an adverse effect on non-lipids. To demonstrate this, we measured the potential for adsorption of various plasma proteins to LRA media. Following the incubation with cryo-reduced source plasma (samples were mixed for three hours at room temperature) soluble protein was measured by nephelometry. The results show that LRA media is specific for lipids and lipid associated proteins within the normal range of additions. Very little non-specific binding of non-lipid associated proteins was observed.

Please Contact Us for specific information and literature on this subject. For more information on Lipid Removal please see the accompanying documentation.